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Etiology of bile duct/gallbladder cancer

In most cases, the cause is unknown.

Risk factors

  • 10–20% of patients with primary sclerosing cholangitis (PSC) will develop cholangiocarcinomas.
  • Chronic infections usually caused by a gallstone may be a factor triggering gallbladder cancer, and about 0.3–3% of patients with gallstones develop gallbladder cancer.
  • A calcified gallbladder (porcelain gallbladder) is more susceptible to gallbladder cancer (1).

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