Etiology of bile duct/gallbladder cancer
In most cases, the cause is unknown.
- 10–20% of patients with primary sclerosing cholangitis (PSC) will develop cholangiocarcinomas.
- Chronic infections usually caused by a gallstone may be a factor triggering gallbladder cancer, and about 0.3–3% of patients with gallstones develop gallbladder cancer.
- A calcified gallbladder (porcelain gallbladder) is more susceptible to gallbladder cancer (1).