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Metastatic patterns of bile duct/gallbladder cancer

Spreading of bile duct cancer often occurs locally in the wall of the gallbladder (intramurally) and along the nerves (perineural), blood vessels (perivascular), and to lymph nodes. Metastasis may often occur to aorta-caval lymph nodes, the liver, and the upper abdominal cavity.  

Spreading of gallbladder cancer can occur to segments 4 and 5 of the liver. Metastasis to local glands and the peritoneum occurs frequently, and metastases are also often detected in the lungs.

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