The prognostic factors for long-term survival are the disease stage and presence of metastases.
For hilar bile duct carcinomas, five year survival is about 30–40%. Tumor-free margins (R0) as well as lymph node negative tumors have the best prognosis (1).
For stage 2 gallbladder cancer, the long-term survival after an extended cholecystectomy is 80–100%. Long-term survival is reduced to 25–50% if there is lymph node metastasis.
In stages 3 and 4, involvement of lymph nodes increases to 60–70%, and long-term survival after surgery is reduced to 15–25%.
Five-year relative survival for patients with bile duct/gallbladder cancer, in percent, during the diagnosis period 1974–2013.
Source: Cancer Registry of Norway