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Allogeneic stem cell transplantation in children

General

An allogeneic stem cell transplant facilitates intensive treatment with chemotherapy that is sometimes combined with total body radiation for leukemia. The treatment eradicates the original bone marrow (myeloablative). This treament can cure otherwise incurable blood diseases. An immunological effect against the remaining leukemia cells is often achieved.

An allogeneic stem cell transplant is performed by transferring hematopoetic stem cells from a donor who usually has an identical tissue type but otherwise genetically different from the patient.

The patient should not have advanced disease and there must be a suitable donor. If it is possible to choose between multiple donors, it is recommended to choose a donor of the same sex. If the patient is CMV negative, the donor should preferably be CMV negative too.

Indications

Acute lymphatic leukemia

  • At the first remission with certain high risk criteria 
  • In second remission (within 6 months after finished chemotherapy). Not after isolated recurrence in CNS or testis. 

Acute myelogenous leukemia

  • In the first remission for high risk criteria 
  • Other remission

Chronic myelogenous leukemia and juvenile myelomonocytic leukemia

  • As soon as possible after the diagnosis

 Goal

  • Cure

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