Most chemotherapy drugs are emetogenic to a greater or lesser extent, and can cause nausea and vomiting. Today, there are effective antiemetic drugs that have reduced the problem significantly.
Nausea is separated into acute nausea and delayed nausea. Acute nausea occurs during the first 24 hours and delayed nausea occurs later than 24 hours after a course of chemotherapy. Delayed nausea is not signficantly improved by antiemetic drugs.
Among the most used chemotherapy drugs in children, cisplatin, procarbazine, and ifosfamide cause delayed nausea and vomiting.