Fever is defined as:
- a single (rectal) temperature ≥ 38.5 °C or
- temperature ≥ 38 °C for more than 2 hours or
- temperature ≥ 38 °C measured three times during 24 hours
There is a known increase of infections when neutrophil < 1.0 x 109/l. The infection risk increases with degree and duration of neutropenia. The neutropenia is considered severe when granulocytes are ≤ 0.5 x 109/l.