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Etiology of esophageal cancer

In most cases, the causes are unknown. However, the development of esophageal cancer is observed in connection with different risk factors.

Spinocellular cancer is related to:

  • alcoholism
  • smoking
  • corrosion damage (exposure to solvents and corrosive chemicals)

Adenocarcinomas are related to:

  • Obesity, with increasing frequency of reflux esophagitis 
  • Intestinal metaplasia (Barrett’s esophagus), which is a result of esophagitis.  

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