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Cervical cancer

Eighty-five percent of cervical cancer develops from the epithelium in the transformation zone. This is the area between the ectocervix and the endocervix (cervical canal).

Epithelium in the transformation zone consists mainly of thin metaplastic epithelium, and is more susceptible to the influence of oncogenes than mature squamous epithelia.

The remaining 15% originate from the glandular epithelium in the cervical canal.


Approximately 0.6% of women will be diagnosed with cervical cancer at some point during their lifetime. The average age at diagnosis is 49 years.

In 2017, it is estimated to be 12,820 new cases of cervical cancer in the United States (17).


Age-specific incidence of cervical cancer, 2010–2014.

Source: National Cancer Institute. Bethesda, MD, USA



Incidence of cervical cancer, 1975–2014.

Source: National Cancer Institute. Bethesda, MD, USA


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