Trophoblastic diseases are staged according to FIGO (The International Federation of Gynecology and Obstetrics) and WHO (World Health Organization) risk scores.
Staging according to FIGO
Stage I: The tumor does not extend beyond the uterus.
Stage II: The tumor extends to the adnexa, parametria, or vagina.
Stage III: Lung metastases. Only lung metastases visible on conventional lung X-ray are included in the scoring system. Small metastases visible only on CT are not included, unless there are many of them.
Stage IV: Metastases to other localization.
|WHO risk score
|| < 4
|Serum h-CG (lU/L)
|Largest tumor ** (cm)
|Number of metastases
* The number of months from last finished pregnancy to start of chemotherapy
** Including uterus
Low risk group: <=6
- Non-metastatic: Stage I
- Metastatic: > Stage I
High risk group: > 6
Placental-site trophoblastic tumors are a special disease group which are only classified according to FIGO stage.