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Symptoms gestational trophoblastic disease

  • Vaginal bleeding
  • Excessive uterine size
  • Prominent ovarian theca-lutein cysts
  • Toxemia, preclampsia
  • Hyperemesis
  • Hyperthyroidism (high hCG)
  • Trophoblastic emboli, respiratory distress

Symptoms of distant metastases:

  • Hemoptysis from lung metastasis
  • Neurologic findings from brain metastasis
  • Hematuria

Some cases start with symptoms from metastases in the absence of local symptoms. Trophoblastic disease should always be considered in women of fertile age with multiple lung metastases.

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