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Uterine cancer

/upload/corpus uteri/corpus.gifUterine cancer includes cancer occurring in the body of the uterus.

These cancer types are:

  • endometrial cancer
  • carcinosarcoma
  • adenosarcoma
  • leiomyosarcoma
  • endometrial stromal sarcoma
  • other types of sarcoma

Endometrial cancer originates from the mucosa of the uterus.

Mixed epithelial and mesenchymal tumors (carcinosarcomas) consist of an epithelial and sarcomatous component. In carcinosarcomas, both components are malignant.

Carcinosarcomas are monoclonal and originate from endometrial carcinoma. The sarcoma component has developed separate from the carcinoma, and is often seen in postmenopausal women. This type behaves biologically as aggressive carcinomas with a high frequency of metastasis, especially to lymph nodes. 

The most common types of sarcomas are leiomyosarcomas and endometrial stromal sarcomas, but all soft-component sarcomas can occur in the uterus. Sarcomas have a biology completely different from carcinomas. The largest difference is that sarcomas almost never metastasize to lymph nodes, but metastasize via blood. They have a great tendency to implantation in the peritoneum if spilled. This is a critical point during surgery. 

Leiomyosarcoma, endometrial stromal sarcoma and adenosarkoma are described in the sarcoma chapter.  

Incidence  

In 2013  there where 768 new cases of uterine cancer diagnosed in Norway. The disease occurs primarily in elderly women, and the average age at diagnosis is 65 years. 

 

Age-specific incidence of uterine cancer, 2009–2013.

Source: Cancer Registry of Norway

 

 

Incidence of uterine cancer, 1954–2013.

Source: Cancer Registry of Norway

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