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Prognosis of uterine cancer


Five-year relative survival for patients with uterine cancer, in percent, according to stage and diagnosis period 1974–2013.

Source: Cancer Registry of Norway

In 2014, there were an estimated 710,228 women living with endometrial cancer in the United States. Most deaths from endometrial cancer occur in women who are middle-aged or older. Death rates have been rising on average 1.4% each year over 2005-2014 (24).

Five-year survival for patients treated during 1993–95  

Patients treated during 1993–95 (22)

Ia 89 %
Ib 90 %
Ic 81 %
IIa 80 %
IIb 72 %
IIIa 63 %
IIIb 39 %
IIIc 51 %
IVa 20 %
IVb 17 %

In addition to stage, the grade of differentiation and histological type are significant.

Seropapillary and clear cell tumors have a high risk for recurrence, even if in stage Ia. These tumors therefore belong to high risk groups (9).

Five-year survival for endometroid type stage I relative to grade of differentiation

Relative to grade of differentiation (22
High = G1 92 %
Moderate = G2 90 %
Low = G3 74 %

Five-year survival for endometrioid type stage I relative to depth of invasion into the myometrium

Relative to depth of invasion (21)
Intramucosal 90 %
< 50 % 82 %
> 50 % 62 %
T1 serosa 49 %

For endometrioid-type tumors, the association between grade of differentiation and myometrial invasion can be derived below.  

Risk grouping for stage I
Stage Differentiation grade
G1 = High G2 = Moderate G3 = Low
la Low Low Moderate
lb Low           Low Moderate
lc Moderate Moderate High


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