Primary radiation therapy is rarely given for endometrial cancer, but may be appropriate for patients with inoperable tumors. In such a case, external radiation therapy is given with 46–50 Gy towards the uterus and iliacal lymph nodes. This is supplemented with brachytherapy to the uterine tumor.
For localized pelvic recurrence which has not previously been treated with radiation, the pelvic tumor is irradiated.
For brain metastases, stereotactic radiation is appropriate for 1 to 3 (max) metastases that are not too large.
For solitary brain metastases, surgery may be appropriate.
Multiple or large brain metastases are treated with total brain irradiation.
For bone metastases, radiation therapy is sometimes given.