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Histology of vaginal cancer

Most tumors originate from squamous epithelia. The pre-stages are separated into vaginal intraepithelial neoplasia (VAIN) 1, 2 and 3 . The most commonly appearing malignant tumor in the vagina is squamous epithelial carcinoma.  

Resected vagina with tumor.
Click to enlarge image.
Photomicrograph of the tumor to the left of type mildly differentiated squamous epithelial carcinoma. Click to enlarge image.

Adenocarcinoma in the vagina is rare. In rare cases, malignant melanoma occurs as a primary tumor.

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