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Histology of cancer of the nasal cavity and paranasal sinuses

Squamous cell carcinoma is the most common cancer type in the nose and sinus. Microscopically they can be divided into keratinizing (the most frequent) and non-keratinizing types.

Adenocarcinomas account for 10–20 % of primary cancers in this region.

Some types of salivary gland cancers can also appear in the sinonasal region. The most common salivary gland cancer of the nasal cavity and paranasal sinuses is adenoid cystic carcinoma.

There are also a number of rare malignant tumors that can occur in the sinonasal region, including:

  • nasopharyngeal carcinoma
  • udifferentiated carcinoma
  • neuroendocrine carcinoma
  • malignant melanoma
  • olfactory neuroblastoma

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