Chronic myeloid leukemia (CML) is a clonal myeloproliferative stem cell disease which is distinguished by an increased number of mature and immature granulocytes in peripheral blood, bone marrow, with increased granulocytopoiesis and splenomegaly.
The disease is defined by the presence of the BCR-ABL fusion gene. This anomaly is probably necessary and sufficient for the development of chronic myeloid leukemia.
- Suspicion of chronic myeloid leukemia
- Confirm the diagnosis
- Identify risk group for disease progression
- Choose the correct treatment and follow-up care