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Diagnosing Chronic Myeloid Leukemia


Typical findings are leukocytosis and the clinical examination often uncovers splenomegaly.

Usually, the neutrophile granulocytes and myelocytes in peripheral blood are > 50 x 109/l (blood resembles bone marrow) . The thrombocyte value may be elevated, normal, or low and anemia is present. 

Basophilia is very common. The bone marrow is abundant with cells and is dominated by granulocytopoeisis which completely matures in the chronic phase.

The diagnosis is confirmed by the presence of the Philadelphia chromosome in the cytogenetic analysis of bone marrow/peripheral blood and detection of BCR-ABL from PCR analysis in peripheral blood.

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