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Etiology of liver cancer

Chronic inflammation, often in connection with a hepatotrophic virus, alfatoxin or alcohol, is observed in connection with the development of hepatocellular carcinoma (HCC).

A common estimate is that 80% of these patients have liver cirrhosis at the time of diagnosis. It is also known that HCC can develop without detectable liver disease.

For intrahepatic cholangiocarcinoma, (IHCC) the etiology is in most cases unknown, however chronic infections, hepatolithiasis, bile duct anomalies, and biliary cystadenoma can lead to development of IHCC.

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