Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (IHCC) often start with uncharacteristic symptomology. IHCC often causes few symptoms and first presents itself when the tumor has reached a considerable size.
When liver cancer progresses, these symptoms will often appear over time:
- weight loss
- reduced general health
- diffuse discomfort in the area
- lack of appetite
- enlarged abdomen
- swollen ankles
- possibly fever
HCC is often discovered during follow-up of patients with a benign liver disease. It is detected by CT or ultrasound. A rise of α-fetoprotein (tumor marker) serum level also causes suspicion of HCC, but only half of those who develop HCC in Norway have a raised α-fetoprotein level.