In most cases, the etiology of lymphoma is unknown, but research shows some possible risk factors.
- Microbes (viruses, bacteria)
- The Epstein-Barr virus (EBV) is incorporated into the genome in subgroups of HL, but does not necessarily cause the disease.
- Impaired immune system
- HIV infection
- Patients receiving immunosuppressive treatment, including organ transplantation patients
- Rare genetic diseases
- Solvents, dyes, and pesticides. Studies have shown a higher frequency of NHL in people exposed to these substances.
Despite accumulation of lymphoma in families, it has not been possible to find a specific genetic disposition.