Nodular lymphocyte-rich Hodgkin's lymphoma most often affects men between the ages of 30 to 50 years and usually presents in stage I or II. The lymphoma usually causes tumor in the neck, axilla, or groin. The mediastinum and bone marrow are rarely involved.
The prognosis is very good for nodular lymphocyte-rich Hodgkin's lymphoma, even though there may be recurrence after time. Also with recurrence, the disease can be cured.
The treatment in early stages (I-IIA) follows the algorithm for classical Hodgkin’s lymphoma. For adanced stages (IIB-IV) the same priniciples are followed as in classical HL, however Rituximab is added to each cycle of chemotherapy.