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Extra nodal marginal zone B-cell lymphoma (MALT lymphoma)

Photomicrograph of HE-stained extra nodal marginal zone B-cell lymphoma. Click to enlarge. Photomicrograph of HE-stained extra nodal marginal zone B-cell lymphoma. Click to enlarge.

Extra nodal marginal cell B-cell lymphoma (MALT lymphoma) originates from mucosa, skin, eyes, and glandular tissue, for example, lung, breast, thyroid, and the GI tract.  

MALT lymphoma has a better prognosis than other indolent lymphomas. 

Treatment 

For confined disease, radiation therapy (2 Gy x 15) is given to cure the disease. Guidelines for radiation therapy follow the same principles as described for confined follicular lymphoma. 

For advanced disease, which is rare, chlorambucil montherapy or rituximab montherapy are first choice options. In rare cases of more aggressive disease, the combination of C(H)OP and rituximab may be considered. For localized stomach lymphomas with identification of Helicobacter pylori, triple elimination treatment with antibiotics has been shown to be effective in uncontrolled studies. It is very important that these patients are examined thoroughly over years with gastroscopy and biopsies. An oncologist should be contacted at a University Hospital.  

 

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