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Anaplastic large cell

Photomicrograph of anaplastic T/0-cell lymphoma.
HE-stained to the left. ALK-1-staining upper right and CD30-staining lower right.

This entity is usually of the T-cell phenotype, but also occurs without confirmation of B- or T-cell origin (0-cells). At histological examination, the cells are usually large with abundant cytoplasm and irregular nuclei and produce CD30 antigen expression. Most lymphomas are positive for the ALK protein, especially men under 40 years. Clinically, the disease presents often in stage III or IV with B symptoms. 

ALK-positive lymphomas have a good prognosis.

ALK-negative lymphomas have a prognosis like the rest of mature T-cell lymphomas.

Treatment

ALK-positive lymphomas are treated with CHOP-analogous chemotherapy regimens.

ALK-negative lymphomas are treated with CHOP14 followed by HDT with SCS for responders.

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