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Splenectomy was previously carried out to determine whether there was involvement of the spleen in patients with lymphoma. Newer image diagnostics, especially use of ultrasound has rendered this procedure unnecessary, and chemotherapy is given instead. If the spleen is involved at the start of treatment, a splenectomy may still be considered in some cases after chemotherapy. This is done to evaluate the presence of residual disease. This procedure is also a good alternative to local radiotherapy.

For splenic marginal B-cell lymphoma, splenectomy is usually indicated as the first treatment choice. 

Splenectomy may also in some cases be carried out to relieve symptoms of splenomegaly and hypersplenism.


  • Splenic marginal zone B-cell lymphoma
  • Other primary splenic lymphoma
  • Other lymphoma with spleen involvement


  • Clarify residual disease
  • Cure the disease 
  • Palliative

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