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Metastatic patterns for multiple myeloma

Thoracic X-ray of tumor with soft tissue component. Click to enlarge image.

Most commonly, myeloma cells spread in the bone marrow of the bones creating multiple small tumors. Hence, the disease is called "multiple myeloma" in English literature.  

In some cases, one localized tumor forms in a single bone, known as a plasmacytoma.  

In rare cases, the disease is also found outside the bone marrow in soft tissue or other organs, and consitutes extramedullary myeloma. In advanced multiple myeloma, the disease can spread to the blood system known as "leukemisation" and is then called plasma cell leukemia. The disease may also manifest itself initially as plasma cell leukemia.

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