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Symptoms and findings of multiple myeloma

Symptoms and findings are caused by the localization of myeloma cells in bone marrow and the effect of the M-component (paraprotein).

  • Bone pain
  • Reduced renal function
  • Anemia, more rarely leukopenia and thrombocytopenia
  • Hypercalcemia due to osteolysis
  • Repeated bacterial infections due to reduced immune system
  • Neuralgia, paralysis, and numbness
  • Signs of amyloidosis, for example large tongue, carpal tunnel syndrome, kidney and/or heart failure
  • Prolonged elevated blood sedimentation rate.
MRI of patient with myeloma in spine. Click to enlarge image. MRI of patient with destruction and collapse of vertebra. Click to enlarge image. X-ray of patient with pathological fracture in humerus. Click to enlarge image.


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