Like other tumors, neuroendocrine tumors spread principally by:
- local infiltration
- lymphogenic spreading
- hematogenic spreading
Besides spreading to local lymph nodes, spreading to the liver is the most common. Spreading to the skeleton and peripheral lymph nodes occurs relatively seldom.
|Octreotide scan showing massive metastasis to the liver, spinal column, and pelvis. Click to enlarge the image.
||MRI of patient with skeletal metastasis in the sacrum and bodies of vertebrae Th6, S2 and S3. (virvelcorpora). Click to enlarge image. |