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Metastatic patterns of neuroendocrine tumors

Like other tumors, neuroendocrine tumors spread principally by:

  • local infiltration
  • lymphogenic spreading
  • hematogenic spreading

Besides spreading to local lymph nodes, spreading to the liver is the most common. Spreading to the skeleton and peripheral lymph nodes occurs relatively seldom.

Octreotide scan showing massive metastasis to the liver, spinal column, and pelvis. Click to enlarge the image. MRI of patient with skeletal metastasis in the sacrum and bodies of vertebrae Th6, S2 and S3. (virvelcorpora). Click to enlarge image.

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