Today, surgery is the only treatment which can cure the patient. All other treatment is palliative. Tumor-reducing treatment, such as hepatic artery embolization and radiofrequency ablation of liver metastases may reduce tumor size and symptoms and might omprove the prognosis.
Biological treatment with interferon and/or somatostatin analogues may stop further growth, and in some cases, reduce the size. The effect of this type of treatment is normally best when treating tumors with low Ki-67%, preferably < 5 %.
Chemotherapy may have an effect, preferably on tumors with high Ki-67%.
External radiation usually has little or no effect, particularly when metastases are located in the skeleton.
Peptide receptor radionuclide therapy (PRRT) may be very effective on subgroups of neuroendocrine tumors, both to reduce the tumor size and to prevent further growth.