Cisplatin and fluoruracil are recommended as adjuvant treatment if > pN1.
For very advanced cases, multimodal treatment with neoadjuvant chemotherapy before surgery may be an option.
PDT (Photo dynamic treatment)
For differentiated and undifferentiated PeIN (CIS and atypical hyperplasia) without visible tumor and no histological suspicion of invading growth, photo dynamic therapy (PDT) may be considered. The principle of this treatment is that the malignant/premalignant cells are sensitized to light of specific wavelength and are destroyed by this light. In principle, this is the same treatment used in some types of superficial skin cancer.