Etiology of prostate cancer
The cause of prostatic cancer is still unclear. Age, heredity, hormones, nutrition, environment, and lifestyle appear to have an influence on the development of the disease. Long-term androgen stimulation is considered to be a premise for developing prostate cancer.
- 10% of prostate cancer cases are of a hereditary disposition. Familial accumulation is a strong risk factor. If one or more in a family have prostate cancer in a relatively young age, this is a strong indicator that the disease is hereditary.
- Mutation of the breast cancer gene BRCA 2 increases the risk significantly. It is known that men with this gene mutation have twenty times the risk of developing prostate cancer before reaching 60 years. These patients are offered special monitoring and follow-up. Men having female relatives with early breast or ovarian cancer should be offered an evaluation for hereditary risk of prostate cancer.