Prostate cells, both normal and malignant, are dependent on testosterone stimulation to grow and divide. This is exploited in palliative treatment of prostate cancer. For metastatic disease, treatment aims at halting production of testosterone. Ninety-five percent of testosterone is produced in the testicles.
Production of testosterone in the testicles is most often done chemically with an injection every three months for life. Alternatively, surgical castration of both testicles can be done operatively.
An orchiectomy can be performed through the inguinal or scrotal area.
- Locally advanced prostate cancer (T3/T4)
- Metastatic prostate cancer (N1/M1)