The prognosis of patients with retroperitoneal sarcomas depends on the disease extent. For patients presenting without metastatic disease, complete surgical resection and histologic grade have been the main determinants of survival.
Complete surgical resection is one of the most important factors for cure or extended survival, as incomplete resection of the tumor or spill of tumor cells during the operative procedure greatly increases the chance for recurrence, and drastically reduces the prognosis.
Other prognostic factors in decreasing order include tumor size, histological subtype, growth pattern, necrosis, vascular and nerve invasion.
The prognosis for localized GIST depends on the size of the tumor and number of mitoses, localization, and the quality of the operative procedure. The prognosis for metastatic GIST has significantly improved after the introduction of imatinib treatment in 2001.
As with other abdominal and pelvic soft tissue sarcomas, the prognosis of gynecological sarcomas is also dependant on presentation and on treatment. Size, histological type and malignancy grade all have prognostic significance.
Prognosis is better for endometrial sarcoma than for uterine leiomyosarcoma.
In localized tumors the quality of the operative treatment is of great prognostic significance.
Prognosis of primary localized soft tissue sarcomas of the anterior abdominal wall is dependent, as in other localizations, on malignancy grade, histologic subtype, size and quality of the operative resection.