Complete surgical resection of the macroscopic tumor combined with chemotherapy is crucial for the prognosis.
Long-term survival of osteosarcoma and Ewing's sarcoma are today 70% for primary extremity localized tumor. Lung and skip-metastases have poorer prognosis.
Osteosarcoma with metastases at the time of diagnosis have long-term survival of approximately 20%.
For Ewing's sarcoma, the long-term survival with lung metastases is 30% and < 10% with both bone and lung metastases.
For chondrosarcoma, chemotherapy and radiation have little effect. Surgical radicality is important for long-term survival which varies between 30-70%.