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Chemotherapy for osteosarcoma in patients < 40 years


The treatment protocol is very intensive, has high toxicity and risk for developing delayed side effects in multiple organs, and requires precise monitoring. The treatment is given only at regional sarcoma centers.
The Scandinavian countries participate in multinational treatment protocols  (Europa, USA). According to the last protocol EURAMOS-I protocol the patients were  randomized based on the histological examination of the operation specimen. Poor responders have a worse prognosis than patients with a good histological response The protocol tests the benefit of modification/intensifying postoperative chemotherapy for patients with poor histological reponse. and addition or not of maintenance therapy with pegylated interferon-alfa in good responders. The protocol was closed June 30th, 2011. Short treatment arm is standard treatment until a new protocol is available.


  • Osteosarcoma in patients ≤ 40 years, any site, metastasis or not


  • Cure the disease
  • Limb-saving surgery

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