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Drug therapy of skin cancer (non-melanoma)

Chemotherapy is used only for palliative purposes and in cases of systemic spread of squamous cell carcinoma. Methotrexate and platininum-based chemotheraphy drugs are the most commonly used groups of medications.

Therapeutic targeting with epidermal growth factor receptor (EGFR) antibodies represents a new treatment opportunity in patients with EGFR-expressing tumors. (6)

For locally advanced and hereditary basal cell carcinoma (Gorlins syndrome), new studies have demonstrated efficacy of small molecular inhibitors (hegdehog inhibitor) against specific intracellular pathways (7). The first drug approved for clinical use is vismodegib Erivedge ®) (8.9

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