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Symptoms of CUP

Symptoms and sign of illness depend on the location of the metastatic tumor. Symptoms may be:

  • a lump in the axilla, groin, or throat
  • pressure/increasing abdomen size (ascites)
  • difficulty breathing 
  • bone pain
  • headache
  • nausea 
  • behavior changes
  • epileptic seizures

Common symptoms often observed in this patient group are anorexia, weight loss, and fatigue.

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